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Trichinella spiralis ESP inhibits tumor cell growth by regulating the immune response and inducing apoptosis
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  • Jing Ding,
  • Xiaolei Liu,
  • Bin Tang,
  • Xue Bai,
  • Yang Wang,
  • Shicun Li,
  • Jian Li,
  • Mingyuan Liu,
  • Xuelin Wang
Jing Ding
Jilin University
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Xiaolei Liu
Jilin University
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Bin Tang
Jilin University
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Xue Bai
Jilin University
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Yang Wang
Jilin University
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Shicun Li
Jilin University
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Jian Li
Jilin University
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Mingyuan Liu
Jilin University
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Xuelin Wang
Jilin University

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Abstract

The excretory-secretory product (ESP) of Trichinella spiralis (T. spiralis) has antitumor activity. To explore the effect of ESP on liver cancer cells, tumor models were established with H22 cells and then infected with T. spiralis. The results showed that the growth of tumors in mice infected with T. spiralis was significantly inhibited. ESP from adult worms or muscle larvae were then incubated with H22 cells in vitro, and it was found that the ESP could inhibit cell proliferation and promote apoptosis. Subsequently, apoptosis-related proteins in stimulated H22 cells were evaluated, and ESP was found to induce cell apoptosis through the mitochondrial pathway. Additionally, Th-related cytokines were investigated in vivo, and the results showed that the levels of Th1 cytokines were significantly increased in the early stage of T. spiralis infection, while Th2 cytokines increased later than Th1 cytokines, implying that Th1 cytokines with antitumor effects may play a role in inhibiting tumor growth at early stage. In short, ESP can directly induce tumor cell apoptosis and indirectly inhibit tumor cell growth through the host immune system, which may be the antitumor mechanism of T. spiralis infection.