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Hospital Information System-Based Pharmacovigilance for Elderly Patients: Practices and Results in China
  • +5
  • Nan Zhou,
  • Zhiyuan Fang,
  • Dong Liang,
  • Jiangping Lian,
  • Huan Han,
  • Peng Zhang,
  • Yan Zuo,
  • Rui Li
Nan Zhou

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Zhiyuan Fang
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Dong Liang
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Jiangping Lian
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Peng Zhang
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Purpose: Multiple diseases are often found in an elderly person concurrently, and most are chronic diseases. A wide variety of drugs are available for treatment but have prominent drugs interaction problems. Our research and development pharmacovigilance system (PVS) for the detection of potentially inappropriate medication (PIM) is a novel alert system which for reducing PIM prescriptions of elderly patients. The aim of this study was to evaluate the effect of a PVS on PIM prescriptions for elderly patients in our hospital. Methods: All drugs that pose risks to elderly patients, risk reasons, grade of recommendation in the guidelines and consensus were concluded, incorporated and summarised as the document information of the PVS for elderly patients. It was imported into the hospital information system (HIS) in batches. The real time audit of different dimensions will be conducted on the medical orders issued according to the different contents of the entries in the PVS. Results: The PVS has been applied into trial operation in the five geriatric departments of our hospital. The PVS for elderly patients has provided warnings 3911 times on outpatient and 3999 times on inpatient for six months. PVS had great influence on the usage of sedatives and hypnotics (estazolam, clonazepam, diazepam, zolpidem, alprazolam). The overall prevalence of PIM was significantly decreased during the 6 months. In January, warning percentage was 16.15% on outpatients and 30.59% on intpatients. However, warning percentage was 6.70% on outpatients and 16.06% on intpatients in June. Conclusions: The combination of the information platform and PIM could provide deeper technical support for the safety of medical behaviour and individualised treatment of patients.