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Rare Cladosporols and Spirobisnaphthalenes from the Chinese toad-derived Cladosporium cladosporioides F-10-2-A
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  • Peng Li,
  • Pan pan Zhang,
  • Xin Hui Wang,
  • Jing Guan,
  • Yu Tong Guo,
  • Liping Lin
Peng Li
Nanjing University of Chinese Medicine
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Pan pan Zhang
Nanjing University of Chinese Medicine
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Xin Hui Wang
Nanjing University of Chinese Medicine
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Jing Guan
Nanjing University of Chinese Medicine
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Yu Tong Guo
Nanjing University of Chinese Medicine
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Liping Lin
Nanjing University of Chinese Medicine

Corresponding Author:[email protected]

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Abstract

Two novel cladosporol derivatives, cladosporols J−K (1−2), and three previously undescribed spirobisnaphthalenes, urnucratins D−F (3−5), as well as eleven known cladosporols (6−16), were characterized from Cladosporium cladosporioides, an endophytic fungus found on the skin of Chinese toad. Cladosporols J−K (1−2) with a single double bond have been rarely reported, while urnucratins D−F (3−5) featured an unusual benzoquinone bisnaphthospiroether skeleton, contributing to an expanding category of rare natural products. Their structures and absolute configurations were determined using extensive spectroscopic methods, including nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS) analyses, as well as through electronic circular dichroism (ECD). Biological assays revealed that compounds 1 and 2 exhibited inhibitory activity against A549 cells, with half maximal inhibitory concentration (IC50) values of 28.22 μM and 32.77 μM, respectively.