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The role of the interleukin family in neuroinflammation caused by substance dependence
  • Xuan Fan
Xuan Fan
Kunming Medical University

Corresponding Author:[email protected]

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Drug abuse is a universal phenomenon that happens across the world. And the neurotoxicity caused by drug abuse in the central nervous system has been extensively studied during the last decade. More recently, the role of drugs causing neuroinflammation, which would subsequently affect dopaminergic neurotoxicity, has aroused wide attention. This paper aims to present a literature review of the studies on the role of the interleukin family in substance-dependent neuroinflammation. Currently, the most studied cytokines in the interleukin family in the drug field are IL-1 and IL-6. In addition, based on the previous literature on changes in interleukin in neuroinflammation induced by different drugs, this paper identifies neuroinflammation-related diseases caused by interleukin families, and summarizes recent advances in the dynamics, mechanisms, immunomodulatory and anti-inflammatory effects that are related to the pathogenesis of these diseases. In conclusion, this review elucidates substance-dependent neurotoxicity from the perspective of interleukin alterations.
17 Oct 2023Submitted to Immunity, Inflammation and Disease
19 Oct 2023Assigned to Editor
19 Oct 2023Submission Checks Completed
19 Oct 2023Review(s) Completed, Editorial Evaluation Pending
26 Oct 2023Reviewer(s) Assigned