Counterion Assisted Stereospecific Nucleophilic Substitution of
Organoborons with Bulky sp3-Carbon Electrophiles
We developed a highly versatile transition metal-free Suzuki type
cross-coupling protocol. Alkenyl/aryl boronic acids could couple
smoothly with bulky Csp3 electrophiles in the presence of mild bases.
The counterion in the base plays a crucial role for the reactivity. Our
metal-free condition is orthogonal towards the classic transition metal
catalyzed Suzuki reactions.