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Potential mechanisms of action of the gut microbiota in antitumour immunity and immunotherapy
  • Qian Yin,
  • Jiao-Jiao Ni,
  • Jie-er Ying
Qian Yin
Zhejiang Cancer Hospital
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Jiao-Jiao Ni
Zhejiang Cancer Hospital
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Jie-er Ying
Zhejiang Cancer Hospital

Corresponding Author:[email protected]

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Abstract

The gut microbiota significantly impacts antitumour immunity and alters the effectiveness of cancer immunotherapy. Immunotherapies, notably inhibitors of immune checkpoints that target programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have profoundly changed the way advanced and metastatic cancer is treated and dramatically improved overall and progression-free survival. However, the underlying molecular mechanisms by which the gut microbiota affects antitumour immunity and the efficacy of cancer immunotherapy remain elusive. In this review, we summarize the latest knowledge supporting the associations among the gut microbiota, antitumour immunity, and immunotherapy. The potential molecular mechanisms underlying these associations are explained in terms of four aspects.
19 Sep 2023Submitted to Immunity, Inflammation and Disease
21 Sep 2023Assigned to Editor
21 Sep 2023Submission Checks Completed
21 Sep 2023Review(s) Completed, Editorial Evaluation Pending
21 Sep 2023Reviewer(s) Assigned