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Nickel-Catalyzed Acid Chlorides with Tetrasulfides for the Synthesis of Thioesters and Acyl disulfides
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  • Wang Chen,
  • Dao-Peng Sheng,
  • Yi-Fang Jiang,
  • Wei-Chen Zhu,
  • Weidong Rao,
  • Shu-Su Shen,
  • Zhao-Ying Yang,
  • Shun-Yi Wang
Wang Chen
Soochow University
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Dao-Peng Sheng
Soochow University
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Yi-Fang Jiang
Soochow University
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Wei-Chen Zhu
Soochow University
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Weidong Rao
Nanjing Forestry University
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Shu-Su Shen
Suzhou University of Science and Technology
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Zhao-Ying Yang
Soochow University
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Shun-Yi Wang
Soochow University

Corresponding Author:[email protected]

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Abstract

Herein, we report a novel method for the synthesis of thioesters and acyl disulfides via nickel-catalyzed reductive cross-electrophile coupling of acid chlorides with tetrasulfides. This approach for the synthesis of thioesters and acyl disulfides is convenient and practical under mild reaction conditions, relying on easy availability. In addition, a wide range of thioesters and acyl disulfides were obtained in medium to good yields with good functional group tolerance. Moreover, thioesters and acyl disulfides can also be prepared at the gram scale, indicating that they have certain potential for industrial application.