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Synthesis of Benzothioamide Derivatives from Benzonitriles and Sulfur-containing Ionic Liquids in Supercritical CO2
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  • Guozhi Sang,
  • Xinchen Wang,
  • Qianxi Feng,
  • Ruijun Xie,
  • Zhuona Li,
  • Enlun Hao,
  • Ruonan Li,
  • Ning Zhu
Guozhi Sang
Inner Mongolia University of Technology
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Xinchen Wang
Inner Mongolia University of Technology
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Qianxi Feng
Inner Mongolia University of Technology
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Ruijun Xie
Inner Mongolia University of Technology
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Zhuona Li
Inner Mongolia University of Technology
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Enlun Hao
Inner Mongolia University of Technology
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Ruonan Li
Inner Mongolia University of Technology
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Ning Zhu
Inner Mongolia University of Technology

Corresponding Author:[email protected]

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Abstract

A simple, efficient and green method has been developed for the synthesis of benzothioamide from benzonitrile in supercritical CO2, which could be used to synthesize various benzothioamide derivatives efficiently without organic solvent. Notably, some sulfur-containing ionic liquids were prepared and they could promote the thiolysis of benzonitrile to produce benzothioamide in an excellent yield. Moreover, the investigation on the reaction mechanism showed that the acid-base property of the reaction solution was key to the thiolysis of benzonitrile mediated by the sulfur-containing ionic liquids.