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Curcumin alleviates IMQ-induced dermatitis and regulates gut microbiota of mice
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  • Yibing Zeng,
  • Zhenguo Cai,
  • wuqing wang,
  • Yao Zhang
Yibing Zeng
fudan daxue fushu zhongshan yiyuan minhang fenyuan

Corresponding Author:[email protected]

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Zhenguo Cai
Shanghai Central Hospital of Minhang District
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wuqing wang
Shuguang Hospital
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Yao Zhang
Shanghai Central Hospital of Minhang District
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Abstract

Background: As a polyphenolic compound originated from the food spice turmeric, curcumin (CUR) has various pharmacological effects, such as anti-inflammatory, anti-oxidation, anti-proliferative and anti-angiogenic activities. Psoriasis is centered on the overproduction of Th1- and Th2-related cytokines (e. g. IL-23, IL-17, TNF-α, IL-22), which is involved in the occurrence and development of its pathogenesis. However, whether CUR is involved in the treatment of psoriasis and its specific mechanisms are not fully understood. Methods: In this study, we detected the therapeutic effect of CUR (100mg/kg· d) on IMQ-induced dermatitis in mice, analyzed by PASI scores, ELISA, HE staining, immunofluorescence. Moreover, we further confirmed the alteration in the relative abundance of the gut microbiota through 16sRNA to explore whether CUR could regulate the gut microbiota of IMQ-induced mice. Result: Through intragastric administration, CUR can alleviate psoriasis-like lesions of mice by decreasing PASI scores, reducing the level of IL-6, IL-17A, IL-22, IL-23, TNF-α and TGF-β1, promoting the expression of IL-10. Moreover, 16 sRNA sequencing revealed that CUR could regulate the alteration in the abundance alteration of gut microbiota related to inflammation, such as Alistipes, Mucispirillum and Rikenella at genus level. The correlation analysis further confirmed the close association between important microflora and psoriasis-like inflammation indicators. Conclusions: CUR exerts the effect of alleviating dermatitis of psoriatic mice by regulating Th-17 related inflammatory factors. Moreover, the changes in gut microbiota via CUR may be another factor of relieving IMQ-induced lesions in mice. Therefore, CUR may be a highly promising candidate for the treatment of psoriasis.
25 May 2023Submitted to Immunity, Inflammation and Disease
31 May 2023Submission Checks Completed
31 May 2023Assigned to Editor
31 May 2023Review(s) Completed, Editorial Evaluation Pending
05 Jun 2023Reviewer(s) Assigned
06 Jul 2023Editorial Decision: Revise Major
20 Jul 20231st Revision Received
21 Jul 2023Submission Checks Completed
21 Jul 2023Assigned to Editor
21 Jul 2023Review(s) Completed, Editorial Evaluation Pending
22 Jul 2023Editorial Decision: Accept