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Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Meningitis with Psychotic Symptoms
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  • Xiaofei Cheng,
  • Qian Yang,
  • Zhewei Su,
  • Linyuan Sun,
  • Mei Wang,
  • Mingli Li
Xiaofei Cheng
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Linyuan Sun
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Mingli Li

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Introduction: Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis is a demyelinating central nervous system disease, whose most common clinical manifestations are optic neuritis, myelitis and acute disseminated encephalitis. However, data on psychotic symptoms in anti-MOG antibody-associated meningitis are still limited. Case description: A 31-year-old female presented with headache, fever, thinking rupture, and dissociative amnesia. Enhancement of the pia mater was found in her magnetic resonance imaging. With antiviral therapies and anti-psychotic treatment, her symptoms didn’t disappear until positive anti-MOG IgG antibody was found in the serum and she received steroid therapy. Conclusion: Psychotic symptoms may be the main manifestation of anti-MOG antibody-associated meningitis. Besides being caused by anti-neuronal antibodies against cell-surface antigens (such as anti-N-methyl-D-aspartate receptor antibodies) and intracellular antigens (such as anti-Hu antibodies), autoimmune psychosis could also occur due to anti-myelin antibodies against MOG. These findings may expand the understanding of this newly described autoimmune disease.
16 May 2023Submitted to Early Intervention in Psychiatry
19 May 2023Assigned to Editor
19 May 2023Submission Checks Completed
19 May 2023Review(s) Completed, Editorial Evaluation Pending
27 May 2023Reviewer(s) Assigned