Recent Advances in the Synthesis of Heterocycles from 2-Acylbenzoic
AbstractHeterocyclics are the crucial scaffolds present in pharmaceuticals,
natural products, biologically active compounds and agrochemicals.
Consequently, the development of simple and practical methods for
constructing heterocyclics has always been a fascinating field in
organic synthesis. Recently, 2-acylbenzoic acids as highly reactive and
versatile synthons have been broadly applied in the construction of
heterocycles due to their multiple reaction sites. In this review, we
summarized recent progress in the application of 2-acylbenzoic acids for
the synthesis of heterocycles including phthalides, isochromanones,
isoindolines, phthalazinones, and quinolones. The sub-strate scopes,
proposed mechanisms, and product application of different types of
reactions are discussed.