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Recent Advances in the Synthesis of Heterocycles from 2-Acylbenzoic Acids
  • Yufeng Liu,
  • Cui Li,
  • Guoping Yang
Yufeng Liu
East China University of Technology
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Cui Li
East China University of Technology
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Guoping Yang
East China University of Technology

Corresponding Author:[email protected]

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Abstract

Heterocyclics are the crucial scaffolds present in pharmaceuticals, natural products, biologically active compounds and agrochemicals. Consequently, the development of simple and practical methods for constructing heterocyclics has always been a fascinating field in organic synthesis. Recently, 2-acylbenzoic acids as highly reactive and versatile synthons have been broadly applied in the construction of heterocycles due to their multiple reaction sites. In this review, we summarized recent progress in the application of 2-acylbenzoic acids for the synthesis of heterocycles including phthalides, isochromanones, isoindolines, phthalazinones, and quinolones. The sub-strate scopes, proposed mechanisms, and product application of different types of reactions are discussed.