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Association of Circulating levels of IL-6 and IL-10 in the Mid Gestation of Pregnant Women with the History of RPL and Extent of pregnancy losses: A South Indian Study
  • Sufaya Jameel,
  • Parveen Jahan
Sufaya Jameel
Maulana Azad National Urdu University

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Parveen Jahan
Maulana Azad National Urdu University
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Abstract

Problem: RPL is loss of two or more clinical pregnancies before 20th week of gestation. Globally, 1-5% couples are affected, with 50% idiopathic RPL cases. Method of Study: The study aimed to assess the circulating levels of IL-6 and IL-10 cytokines. A total of 170 pregnant women in their second-trimester with and without the history of RPL were enrolled from Niloufer Hospital, south-India. Serum samples isolated from blood were subjected to ELISA for the estimation of the above cytokines. Results: Analysis of data revealed significantly elevated IL-6 and reduced IL-10 levels in RPL group compared to NRPL group (P=0.0001). Moreover, IL-6/IL-10 ratio differed significantly between the two study groups. ROC curve analysis for cytokine ratios were superior to individual IL-6 and IL-10 cytokines for RPL group over the NRPL group. Further, data from RPL group (2 and >2 pregnancy losses) revealed heightened inflammation in >2 pregnancy losses compared to 2 losses. These results clearly indicate that pro-inflammatory systemic milieu exist in the mid gestation of pregnant women with the history of RPL that may be reflecting feto-palcental environment. Conclusion: Further studies creating a cytokine signature for these two groups may help in developing better preventive/management strategies by cytokine based therapeutics.