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Sesterterpenoids with uncommon frameworks and polyketides from a deep sea-sediment-sourced fungus Chaetomium globosum SD-347
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  • Xiao-Dong Li,
  • Xin Li,
  • Xiao-Ming Li,
  • Xiu-Li Yin,
  • Bin-Gui Wang
Xiao-Dong Li
Institute of Oceanology, Chinese Academy of Sciences
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Xin Li
Institute of Oceanology, Chinese Academy of Sciences
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Xiao-Ming Li
Institute of Oceanology, Chinese Academy of Sciences
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Xiu-Li Yin
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences
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Bin-Gui Wang
Institute of Oceanology, Chinese Academy of Sciences

Corresponding Author:[email protected]

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Abstract

Two new sesterterpenoids sesterchaetins A and B (1 and 2) and two new polyketides chaetoketones A and B (3 and 4) were characterized from the culture extract of a deep sea-sediment-derived fungal strain Chaetomium globosum SD-347. Their structures including absolute configurations were unambiguously solved by detailed NMR, mass spectra, and X-ray crystallographic analysis. Compounds 1 and 2 contained a characteristic 5/8/6/5 tetracyclic carbon-ring-system, which represented rarely occurring natural product frameworks. The new isolates 14 exhibited selective antimicrobial activities against human and aquatic pathogenic bacteria and plant-pathogenic fungi.