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Comprehensive Proteomic Characterization of Scar Formation in Urethral Stricture Disease
  • +8
  • Chen Ding,
  • Jiangtao Gao,
  • Chunmei Guo,
  • Lingling Li,
  • Hui Liu,
  • Zhiyong Wang,
  • Mengya Cheng,
  • Chao Feng,
  • Jijing Shi,
  • Lu Chen,
  • Hui Wu
Chen Ding
Fudan University

Corresponding Author:[email protected]

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Jiangtao Gao
Zhengzhou First People Hospital
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Chunmei Guo
Fudan University
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Lingling Li
Fudan University
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Hui Liu
Fudan University
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Zhiyong Wang
Zhengzhou First People Hospital
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Mengya Cheng
Zhengzhou First People Hospital
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Chao Feng
Shanghai Jiaotong University Affiliated Sixth People Hospital South Campus
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Jijing Shi
Zhengzhou First People Hospital
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Lu Chen
Zhengzhou First People Hospital
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Hui Wu
Zhengzhou First People Hospital
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Abstract

Male urethral stricture disease (USD) is characterized by scar formation, and the molecular mechanism is still lack. In this study, we performed comprehensive proteomic landscape of USD with 12 scar tissues and 5 matched normal adjacent tissues (NATs). Comparative analysis disclosed the ECM signaling and complement cascade were overrepresented in the scar tissues, in which COL11A1, CNN2, and CD248 would play positive impacts. In addition, we revealed the diverse molecular mechanism of scar formation of USD with different ages, and proposed the potential effects of PXK in the Age 1 (< 45) patients. Furthermore, the immune infiltration of USD indicated the medicative of inhibition of complement system (C4A, C4B) in the Age 2 (≥ 45) patients. Collectively, this study provides insight into understanding the molecular mechanism of scar formation, and delivered a valuable resource for the development of therapeutic targets for USD.