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A Pan-cancer Analysis of Kelch Like Family Member 38 (KLHL38) Alterations in Human Cancers
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  • Linyue Hai,
  • Yuetong Liu,
  • Shuai Meng,
  • Jingjing Zhao,
  • Bowen Liu,
  • Zhidong Huang,
  • Xuchen Cao,
  • Hong Liu,
  • Chunhua Xiao
Linyue Hai
Tianjin Medical University Cancer Institute and Hospital

Corresponding Author:[email protected]

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Yuetong Liu
Tianjin Medical University Cancer Institute and Hospital
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Shuai Meng
Tianjin Medical University Cancer Institute and Hospital
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Jingjing Zhao
Tianjin Medical University Cancer Institute and Hospital
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Bowen Liu
Tianjin Medical University Cancer Institute and Hospital
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Zhidong Huang
Tianjin Medical University Cancer Institute and Hospital
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Xuchen Cao
Tianjin Medical University Cancer Institute and Hospital
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Hong Liu
Tianjin Medical University Cancer Institute and Hospital
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Chunhua Xiao
Tianjin Medical University Cancer Institute and Hospital
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Abstract

Background: Growing evidence suggests that the KLHL family may be involved in the occurrence and development of cancer. KLHL38, a member of the KLHL protein family, contains BTB/POZ, BACK domains, and five to six Kelch motifs. However, no pan-cancer analyses have been conducted on KLHL38. In this study, we aimed to explore the potential biological functions of KLHL38 that may provide potential tumor-related therapeutic targets. Methods: The potential roles of KLHL38 in different tumor types were explored based on The Cancer Genome Atlas (TCGA), Genotype-tissue expression (GTEx), Tumor Immune Estimation Resource (TIMER), and Gene Set Enrichment Analysis (GSEA) datasets. Several factors related to KLHL38 were analyzed, including expression differences, survival, pathological stage, DNA methylation, tumor mutation burden (TMB), tumor microenvironment (TME), stemness score, and immune cell infiltration. Results: There were significant differences in KLHL38 expression among different cancer types and between cancer tissue and normal tissue, which was closely correlated with survival prognosis. Furthermore, KLHL38 expression was found to be correlated with DNA methylation, tumor mutations, and stemness scores in major cancer types, suggesting its involvement in cancer development. To some extent, KLHL38 expression levels were significantly correlated with immune cell infiltration, immune checkpoint genes, and immune regulatory genes. These results indicated that KLHL38 can be used as a tumor prognostic indicator. Conclusion: In our study, we analyzed the role of KLHL38 role in tumor development and immunotherapy, which may provide a potential new target for tumor treatment.