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The growing relevance of microRNAs as a diagnostic marker for breast cancer
  • Desmond Moher,
  • Frank Mosby,
  • Lisa Smith
Desmond Moher
Department of Molecular Biology, University of Arizona

Corresponding Author:[email protected]

Author Profile
Frank Mosby
Department of Biological Sciences, University of Albany
Lisa Smith
Department of Genetics, Auburn University

Abstract

Because the breast is seen as a symbol of beauty, sexuality, and motherhood, a woman diagnosed with breast cancer has extreme emotional stress during the inquiry, diagnosis, and treatment processes. The breast has several symbolic and sexual functions in addition to its fundamental function of nourishing infants. Numerous serum proteins and naturally occurring oncogenic genes have been investigated as possible biomarkers for breast cancer (BC) as cutting-edge molecular technologies like microarray and RNA/DNASeq have advanced. Small, non-coding microRNAs have emerged as key regulators in oncogenesis pathways and as potential non-invasive biomarkers for clinical diagnosis. This emerging chemical for cancer detection and prognosis belongs to a new family of noninvasive biomarkers. Insights into the principles of tumor growth and the identification of potential early powerful noninvasive indicators for early diagnosis of breast cancer may result from a better knowledge of the role of miRNAs in carcinogenesis. Recent clinical research has shown that miRNAs may be found in bodily fluids including serum and plasma, suggesting that they might be used as noninvasive biomarkers of illness. In this review, we compile the latest data demonstrating miRNAs' value as an innovative early diagnostic and prognostic tool. Here, we present the clinical use and applicability of miRNAs in breast cancer, which might inform future early stage detection techniques.