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An NTRK1-associated Genes Classification Predicts Prognosis in Pediatric Sarcoma Cases
  • Lianyuan Yu,
  • Lejian HE
Lianyuan Yu
Beijing Children's Hospital Capital Medical University

Corresponding Author:[email protected]

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Lejian HE
Beijing Children's Hospital Capital Medical University
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Abstract

Introduction: NTRK-rearranged spindle cell neoplasm is an emerging tumor entity. The genetic mechanisms and prognostic implications of this entity are mainly unknown. The corresponding targeting therapy strategies have been widely developed. Method: In this study, we summarized the immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) characteristics. Also, we have explored the genetic mechanisms and prognostic implications of this entity. Results: We identified two NTRK1-associated gene sub types by consensus clustering. Besides, we established an NTRK1-associated gene prognostic model that predicted the survival of Sarcoma (SARC) based on the TCGA dataset. Two NTRK1-associated genes are related to the prediction of clinical outcomes. Discussion/Conclusion: A new classification system of SARC based on NTRK1-associated gene signatures has been established.