An NTRK1-associated Genes Classification Predicts Prognosis in Pediatric
Introduction: NTRK-rearranged spindle cell neoplasm is an
emerging tumor entity. The genetic mechanisms and prognostic
implications of this entity are mainly unknown. The corresponding
targeting therapy strategies have been widely developed.
Method: In this study, we summarized the immunohistochemistry
(IHC) and fluorescence in situ hybridization (FISH) characteristics.
Also, we have explored the genetic mechanisms and prognostic
implications of this entity. Results: We identified two
NTRK1-associated gene sub types by consensus clustering. Besides, we
established an NTRK1-associated gene prognostic model that predicted the
survival of Sarcoma (SARC) based on the TCGA dataset. Two
NTRK1-associated genes are related to the prediction of clinical
outcomes. Discussion/Conclusion: A new classification system of
SARC based on NTRK1-associated gene signatures has been established.