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Gold/Cobalt Ferrite Nanocomposite as a Potential Agent for Photothermal Therapy
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  • Anna V. Motorzhina,
  • Stanislav E. Pshenichnikov,
  • Anton A. Anikin,
  • Victor K. Belyaev,
  • Alexander Yakunin,
  • Sergey V. Zarkov,
  • Valery Tuchin,
  • Sonja Jovanović,
  • Claudio Sangregorio,
  • Valeria V. Rodionova,
  • Larissa V. Panina,
  • Kateryna V. Levada
Anna V. Motorzhina
Baltijskij federal'nyj universitet imeni Immanuila Kanta
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Stanislav E. Pshenichnikov
Baltijskij federal'nyj universitet imeni Immanuila Kanta
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Anton A. Anikin
Baltijskij federal'nyj universitet imeni Immanuila Kanta
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Victor K. Belyaev
Baltijskij federal'nyj universitet imeni Immanuila Kanta

Corresponding Author:[email protected]

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Alexander Yakunin
Federal Research Centre "Saratov Scientific Centre of the Russian Academy of Sciences
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Sergey V. Zarkov
Federal Research Centre "Saratov Scientific Centre of the Russian Academy of Sciences
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Valery Tuchin
Federal Research Centre "Saratov Scientific Centre of the Russian Academy of Sciences
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Sonja Jovanović
Univerzitet u Beogradu Institut za nuklearne nauke Vinca
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Claudio Sangregorio
Istituto di Chimica dei Composti Organo Metallici Consiglio Nazionale delle Ricerche
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Valeria V. Rodionova
Baltijskij federal'nyj universitet imeni Immanuila Kanta
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Larissa V. Panina
Baltijskij federal'nyj universitet imeni Immanuila Kanta
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Kateryna V. Levada
Baltijskij federal'nyj universitet imeni Immanuila Kanta
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Abstract

Composite nanoparticles with a gold core enveloped by cobalt ferrite nanoparticles show potential for enhanced photothermal therapy. Determining the optimal gold-to-cobalt ferrite nanoparticle ratio, dependent on size, is vital for improving treatment efficiency. We address the urgent need for advancing photothermal therapy through utilising combined plasmon-magnetic composites with potential of controlled directional delivery. Our computational modeling and experimental absorption spectra analysis reveal that adjusting the cobalt ferrite nanoparticle content redshifts the plasmon resonance frequency in gold nanoparticles, which is accompanied by increase in the extinction cross-section. As a result, cobalt ferrite nanoparticle absorption dominates. Our experiments on photothermal response in aqueous solutions of composite nanoparticles of various concentrations demonstrate that 100 μg/ml solution yields a significant temperature increase of ~8.2 K and a photothermal conversion efficiency of ~51%. At this concentration, the composite nanoparticles effectively heat the cell culture medium under photothermal conditions, leading to 22% reduction in cell viability.
14 Nov 2023Submitted to Journal of Biophotonics
15 Nov 2023Assigned to Editor
15 Nov 2023Submission Checks Completed
15 Nov 2023Review(s) Completed, Editorial Evaluation Pending
15 Nov 2023Reviewer(s) Assigned