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MiRNAs Play a Functional Role in the Development of In Situ Breast Carcinoma
  • Julia Wisniewski,
  • Agnieszka Kozlowski
Julia Wisniewski
Department of oncology, Medical University of Warsaw

Corresponding Author:[email protected]

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Agnieszka Kozlowski
Department of oncology, Medical University of Warsaw

Abstract

MicroRNAs (miRNAs) are a kind of tiny RNA that regulates gene expression by snatching up mRNA. MicroRNAs (miRNAs) may have a role in either promoting or inhibiting tumor growth depending on the activity of the genes they target. Even though DCIS is often misdiagnosed as breast cancer, it may be a precursor to invasive ductal carcinoma. The preinvasive stage of DCIS is characterized by alterations in the expression of miRNAs and other genetic processes necessary for the invasive development of DCIS. MicroRNAs have been shown to have a role in breast cancer development by regulating oncogenic and tumor-suppressive pathways. Hormone signaling, cell-cell adhesion, epithelial-to-mesenchymal transition, transforming growth factor signaling, maintenance of cancer stem cells, and manipulation of the extracellular matrix are all processes that have been demonstrated to be influenced by miRNAs in DCIS. Furthermore, exosomal DCIS miRNAs may enhance invasive growth by altering the tumor microenvironment. In this article, we take a look back at the miRNAs that have been linked to DCIS and how they may play a role in the development of invasive disease. We also briefly review the present status of miRNA treatment development and the problems that have been encountered so far, as well as the important future prospects for research into miRNA function with the goal of miRNA therapy development for DCIS.