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Breast cancer lncRNA-microRNA categories: new targets for therapeutic intervention
  • Lorenzo Bruno ,
  • Lorenzo Bruno,
  • Luca Rossi
Lorenzo Bruno

Corresponding Author:[email protected]

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Lorenzo Bruno
Physiological Sciences Department, University of Turin
Luca Rossi
Physiological Sciences Department, University of Turin


Breast cancer therapy may fail due to the disease's limiting pathogenesis processes, including as epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), and drug resistance. Functionally significant mediators in these pathogenic processes include lncRNAs and miRNAs, which are master regulators of gene expression. Complex regulatory networks of post-transcriptional gene control are formed by the intricate crosstalks between these non-coding RNAs. The lncRNA-miRNA axis may have tumor suppressor or oncogenic effects depending on the individual lncRNA/miRNA interaction, making its definition crucial for establishing targetability. We provide a comprehensive review of the literature on lncRNA-miRNA interactions in breast cancer, highlighting their role in the molecular pathways that control EMT, CSCs, and treatment resistance. We also discuss the possible new mechanisms of lncRNA-miRNA interactions in breast cancer and examine the well-studied mechanisms already known to exist.