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Vaccines and other factors associated with 1-year HPV vaccination among girls attending Spanish Primary Care settings
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  • Belén Castillo-Cano,
  • Marc Comas-Cufí,
  • Aida Moreno,
  • Elisa Martin Merino
Belén Castillo-Cano
Agencia Espanola de Medicamentos y Productos Sanitarios
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Marc Comas-Cufí
Universitat de Girona Parc Cientific i Tecnologic
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Aida Moreno
Instituto de Investigacion Sanitaria Aragon
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Elisa Martin Merino
Agencia Espanola de Medicamentos y Productos Sanitarios

Corresponding Author:[email protected]

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Objective To identify primary care recorded factors associated with the short-term human papillomavirus (HPV) vaccination among girls and female adolescents. Methods We used the Spanish Pharmacoepidemiological Research Database for Public Health System to identify girls aged 9-18 years in 2007-2016 with ≥1 year of primary care data (start date) and collect baseline characteristics and consultations. The link between those factors and the 1-year HPV vaccination was assessed through multivariate adjusted Odds Ratios (OR; 95% CI). Results Among 388,669 girls identified, 14,999 were vaccinated against HPV during the first year. The vaccination decreased among girls consulting for social (0.62; 0.55-0.70) or adaptation (0.60; 0.38-0.93) problems, prescriptions of benzodiazepines (0.58; 0.35-0.94) or drugs for gastrointestinal symptoms (0.58; 0.38-0.89), with recorded tuberculosis test (0.68; 0.52-0.87), B and C meningitis (0.46; 0.43-0.50) vaccination, consulting the doctor in the last 3 months (0.92; 0.87-0.98) and with severe thinness (0.68; 0.59-0.78) or obesity (0.88; 0.78-0.99). The odds increased among girls with abdominal pain (1.10; 1.04-1.16), prescriptions in the last 3 months (1.17; 1.10-1.25), and vaccinations against chickenpox (1.16; 1.07-1.27), influenza (1.23; 1.08-1.40), hepatitis (1.46; 1.35-1.58) and diphtheria-tetanus (1.91; 1.82-2.01). Conclusions The correlation between the HPV and other vaccinations suggested medical (contra)indications or willingness and knowledge/beliefs that might affect different vaccinations similarly. The higher frequency of the HPV vaccination among females requiring specific treatments or with abdominal pain suggested vulnerability to HPV complications. While a decreased HPV vaccination linked to certain social and personal situations (and benzodiazepines treatment) requires further research.
08 Nov 2023Submitted to Pharmacoepidemiology and Drug Safety
08 Nov 2023Review(s) Completed, Editorial Evaluation Pending
08 Nov 2023Assigned to Editor
08 Nov 2023Submission Checks Completed
15 Nov 2023Reviewer(s) Assigned