Effect of 24-h and 36-h Acute Total Sleep Deprivation on Human
Attention: An Activation Likelihood Estimation Meta-analysis
Abstract Background: Currently, there is no consensus on the effect of
24-h and 36-h acute total sleep deprivation (ATSD) on human attention.
This activation likelihood estimation (ALE) meta-analysis aimed to
compare the different patterns of functional magnetic resonance imaging
(fMRI activation) between 24-h and 36-h ATSD across attention tasks.
Methods: We used GingerALE 2.3.6 software to conduct coordinate-based
ALE meta-analysis. The literature related to sleep deprivation,
attention, and neuroimaging was searched in four databases: CNKI,
PubMed, Web of Science, and PsycINFO from November 1980 to March 2023.
Results: We included 16 fMRI-related articles, with 383 participants and
95 foci. The findings revealed that 24-h ATSD and 36-h ATSD may impair
different brain areas. After 24-h ATSD, there was significantly reduced
brain activation in the parietal-occipital attention lobes and the
salience network, including the bilateral superior parietal lobule,
right inferior occipital gyrus, and left insula. Increased activation
was observed in the sub-lobar regions, including the bilateral thalamus.
After 36-h ATSD, there was significantly reduced activation in the
frontoparietal attention network, including the left middle frontal
gyrus and the right inferior frontal gyrus. Conclusions: This ALE
meta-analysis revealed that prolonged ATSD leads to more severe
temporary brain damage and a cumulative decrease in the external stimuli
captured by humans. This primarily affects the
frontal-parietal-occipital attention network and the salience network.
Thalamic activation may compensate for dysfunction in the
parietal-occipital attention network after 24-h ATSD. Sleep deprivation
duration plays a crucial role in the extent of attention impairment.