loading page

Deinococcus wulumuqiensis R12 synthesized silver nanoparticles with peroxidase-like activity for synergistic antibacterial application
  • +4
  • Jingjia Liu,
  • Nan Zhang,
  • Bowen Shen,
  • Liling Zhang,
  • Zhidong Zhang,
  • Liying Zhu,
  • Ling Jiang
Jingjia Liu
Author Profile
Bowen Shen
Author Profile
Liling Zhang
Author Profile
Zhidong Zhang
Author Profile
Liying Zhu

Corresponding Author:[email protected]

Author Profile
Ling Jiang
Author Profile

Abstract

The use of a combination of several antibacterial agents for therapy holds great promise in reducing the dosage and side effects of these agents, improving their efficiency, and inducing potential synergistic therapeutic effects. Herein, R12-AgNPs were produced with the supernatant of an ionizing radiation-tolerant bacterium Deinococcus wulumuqiensis R12 by one-step under room temperature. The biosynthesized AgNPs presented fascinating antibacterial activity and peroxidase-like properties, which endowed it with the capability to catalyse the decomposition of H2O2 to generate hydroxyl radical. After combination of R12-AgNPs and H2O2, an excellent synergistic bacteriostatic activity was observed for both E. coli and S. aureus, especially at low concentrations. In addition, in vitro cytotoxicity tests showed R12-AgNPs had good biocompatibility. Thus, this work presents a novel antibacterial agent that exhibits favorable synergistic antibacterial activity and low toxicity, without the use of antibiotics or a complicated synthesis process.
27 Oct 2023Submitted to Biotechnology Journal
27 Oct 2023Assigned to Editor
27 Oct 2023Submission Checks Completed
27 Oct 2023Review(s) Completed, Editorial Evaluation Pending
28 Oct 2023Reviewer(s) Assigned