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In situ automatic deposition of PLGA/PLLA composite nanofibrous membranes for personalized wound dressing
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  • Yuzhi Liu,
  • Bihan Xia,
  • Rui Zhao,
  • Mei Qin,
  • Xuan Weng,
  • Kai Deng,
  • Zhi Zeng,
  • Yu Bao,
  • Hai Jiang
Yuzhi Liu
West China Hospital of Sichuan University
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Bihan Xia
West China Hospital of Sichuan University
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Rui Zhao
West China Hospital of Sichuan University
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Mei Qin
University of Electronic Science and Technology of China School of Mechanical and Electrical Engineering
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Xuan Weng
University of Electronic Science and Technology of China School of Mechanical and Electrical Engineering
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Kai Deng
West China Hospital of Sichuan University
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Zhi Zeng
University of Electronic Science and Technology of China School of Mechanical and Electrical Engineering
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Yu Bao
Sichuan Cancer Hospital and Institute
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Hai Jiang
University of Electronic Science and Technology of China School of Mechanical and Electrical Engineering

Corresponding Author:[email protected]

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Abstract

Improving mechanical properties of wound dressings and achieving personalized automatic real-time in situ deposition are important to accelerate wound management and repair. In this study, we reported a home designed automatic in situ deposition device based on solution blow spinning (SBS) to prepare PLGA/PLLA composite nanofibrous membranes for wound dressing. Polymer solution and in situ deposition conditions including air pressure, spinning distance, solvent extrusion rate, and spinning rate were optimized by orthogonal experiments and characterized with dynamic mechanical analysis. Microscopic morphology and physical properties of the prepared PLGA/PLLA composite nanofibrous membranes show that the strength, adhesion, water vapor transmission rate, water retention, water absorption, degradation etc., were sufficient for wound dressing applications. To investigate the possibility as a biomedical wound-dressing material, tannic acid (TA) was incorporated with PLGA/PLLA composite nanofibrous membranes. The resultant PLGA/PLLA/TA composite nanofibrous membranes exhibited good biocompatible and exceptional antibacterial properties against both Escherichia coli and Staphylococcus aureus. A pilot animal study illustrated the potential of this in situ deposition of PLGA/PLLA/TA composite nanofibrous membranes across multiple applications in wound healing/ repair by reducing the formation of wound scar tissue and overactivation of fibroblasts.