In situ automatic deposition of PLGA/PLLA composite nanofibrous
membranes for personalized wound dressing
Improving mechanical properties of wound dressings and achieving
personalized automatic real-time in situ deposition are important
to accelerate wound management and repair. In this study, we reported a
home designed automatic in situ deposition device based on
solution blow spinning (SBS) to prepare PLGA/PLLA composite nanofibrous
membranes for wound dressing. Polymer solution and in situ
deposition conditions including air pressure, spinning distance, solvent
extrusion rate, and spinning rate were optimized by orthogonal
experiments and characterized with dynamic mechanical analysis.
Microscopic morphology and physical properties of the prepared PLGA/PLLA
composite nanofibrous membranes show that the strength, adhesion, water
vapor transmission rate, water retention, water absorption, degradation
etc., were sufficient for wound dressing applications. To investigate
the possibility as a biomedical wound-dressing material, tannic acid
(TA) was incorporated with PLGA/PLLA composite nanofibrous membranes.
The resultant PLGA/PLLA/TA composite nanofibrous membranes exhibited
good biocompatible and exceptional antibacterial properties against both
Escherichia coli and Staphylococcus aureus. A pilot animal
study illustrated the potential of this in situ deposition of
PLGA/PLLA/TA composite nanofibrous membranes across multiple
applications in wound healing/ repair by reducing the formation of wound
scar tissue and overactivation of fibroblasts.