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The Relationship Between Tumor Budding and Clinical Pathological Characteristics of Cervical Cancer and Its Prognostic Significance:A Meta Analysis
  • * ZhangSong,
  • GuoLin *,
  • * QiuShan
* ZhangSong
ChongQing Ninth People’s Hospital

Corresponding Author:[email protected]

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GuoLin *
Xi'an Daxing Hospital
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* QiuShan
AnZhou District Traditional Chinese Medicine Hospital
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Objective: To explore the relationship between tumor budding and clinical pathological characteristics and prognosis of cervical cancer; Methods: By searching Pubmed, Embase, Cochren, CNKI and CBM databases, the research studies on the relationship between tumor budding and prognosis or clinic-pathological characteristics of cervical cancer were included. The quality of researches included was evaluated according the Castle Ottawa Scale (NOS) and statistically analyzed by Stata 12.0. Result: A total of 10 studies were included, including 11 cohorts. Including 2017 patients, the NOS score of these studies is more than 6 points. Tumor budding is related to age and tumor size of cervical cancer. In part of pathological characteristics, squamous cell carcinoma, higher stage, lymph node metastasis, distant metastasis, high WHO grade, deep interstitial invasion, Lymphatic vessel vascular space invasion, nerve invasion and para uterine invasion are more likely to occur tumor budding, occurrence of tumor sprouting in C-type cervical adenocarcinoma is higher than that in A/B type; In univariate analysis, there was a significant correlation between cervical cancer tumor sprouting and disease-free survival in patients (RR=6.511,P=0.000), in multivariate analysis, there was also a significant correlation between those (HR=3.358,P=0.001); Subgroup analysis of univariate analysis showed that Asian (RR=1.879, P=0.000), sample size ≤ 300 (RR=1.875, P=0.000), inclusion of squamous cell carcinoma (RR=1.884, P=0.000), staging criteria (FIGO and TNM), and tumor staging (I-II and mixed staging) all had an impact on DFS.Conclusion: The clinical application of tumor budding as a prognostic factor of cervical cancer can be considered.
19 Oct 2023Submitted to Cancer Reports
25 Oct 2023Assigned to Editor
25 Oct 2023Submission Checks Completed
25 Oct 2023Review(s) Completed, Editorial Evaluation Pending
17 Nov 2023Reviewer(s) Assigned