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Epidemiology and prognostic factors of bloodstream infections among adolescents and young adults with acute lymphoblastic leukemia: an 11-years of retrospective cohort study
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  • longlong xue,
  • Yishu Tang,
  • Liwen Wang,
  • Cong Xu,
  • Qian Cheng,
  • Xin Li
longlong xue
Central South University Third Xiangya Hospital
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Yishu Tang
Central South University Third Xiangya Hospital
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Liwen Wang
Central South University Third Xiangya Hospital
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Cong Xu
The Seventh Affiliated Hospital Sun Yat-sen University Department of Rehabilitation Medicine
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Qian Cheng
Central South University Third Xiangya Hospital
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Xin Li
Central South University Third Xiangya Hospital

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Abstract

Adolescent and young adults (AYAs) belong to a unique category of patients diagnosed with acute lymphoblastic leukemia (ALL) who have better outcomes when treated with pediatric-inspired regimens. Bloodstream infections (BSIs) is a leading cause of treatment-related mortality in ALL patients. However, the epidemiology and prognostic characteristics of BSIs in ALL patients with AYAs remain unclear. In this study, we analyzed the epidemiology and prognostic factors of AYAs and compared the similarities and differences between younger and older adult patients with BSIs. We analyzed the clinical data of three comprehensive hospitals in Hunan Province, China, from January 2010 to August 2021. In this study, the clinical characteristics and pathogen distributions of AYAs patients were similar to those of adult ALL patients. Extended-spectrum beta-lactamase(ESBL)-producing bacteria were more commonly found in AYAs than in children (32.8% vs. 16.4%, P=0.09). Regarding prognostic factors, the length of hospitalization (>14 days) and renal inadequacy (creatinine≥177μmoI/L) were risk factors for 30-day mortality in AYAs with BSIs. In our study, AYAs patients with BSIs showed clinical characteristics and pathogen distributions similar to those of adult patients, but were quite different from those of children.
21 Oct 2023Submitted to Clinical and Experimental Pharmacology and Physiology
25 Oct 2023Assigned to Editor
25 Oct 2023Submission Checks Completed
25 Oct 2023Review(s) Completed, Editorial Evaluation Pending
30 Oct 2023Reviewer(s) Assigned