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Hypersensitivity reactions to Proton Pump Inhibitors. An EAACI Position Paper
  • +9
  • Sevim Bavbek,
  • Seçil Kepil Özdemir,
  • patrizia Bonadonna,
  • Marina Atanasković-Marković,
  • Annick BARBAUD,
  • Knut Brockow,
  • José Laguna,
  • Alla Nakonechna,
  • Alessandra Arcolaci,
  • Mauro Pagani,
  • Lombardo Carla,
  • María José Torres
Sevim Bavbek
Ankara Universitesi Immunoloji ve Allerji Hastaliklari Bilim Dali

Corresponding Author:[email protected]

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Seçil Kepil Özdemir
Doktor Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi
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patrizia Bonadonna
Azienda Ospedaliera Universitaria Integrata Verona
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Marina Atanasković-Marković
Univerzitet u Beogradu Medicinski fakultet
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Institut Pierre Louis d'Epidemiologie et de Sante Publique
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Knut Brockow
European University - Munich
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José Laguna
Hospital Universitario de Madrid
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Alla Nakonechna
Lancashire Teaching Hospitals NHS Foundation Trust
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Alessandra Arcolaci
Azienda Ospedaliera Universitaria Integrata Verona Sede di Borgo Roma
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Mauro Pagani
Azienda Socio Sanitaria Territoriale di Mantova
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Lombardo Carla
Provincia autonoma di Trento Azienda Provinciale per i Servizi Sanitari
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María José Torres
Hospital Regional Universitario de Malaga
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Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.
25 Oct 2023Submitted to Allergy
25 Oct 2023Assigned to Editor
25 Oct 2023Submission Checks Completed
25 Oct 2023Review(s) Completed, Editorial Evaluation Pending
26 Oct 2023Reviewer(s) Assigned
09 Nov 2023Editorial Decision: Accept