loading page

Animal models in Epilepsy
  • Jefry Winner G,
  • Anusha Natarajan
Jefry Winner G

Corresponding Author:[email protected]

Author Profile
Anusha Natarajan
Jawaharlal Institute of Postgraduate Medical Education and Research
Author Profile


Epilepsy, characterized by recurrent seizures, encompasses various complex syndromes with varied origins. To unravel the intricate biology of epilepsy and explore novel Antiseizure treatments, researchers have developed over 100 in vitro and in vivo epilepsy models, each simulating different seizure types. These experimental models serve as indispensable tools for investigating the neurochemical, neurophysiological, cellular, and molecular mechanisms governing epileptic seizures, offering a comprehensive understanding of this condition. This article provides a comprehensive overview of diverse experimental models crucial for studying Antiseizure Medication and seizures, including Generalized Tonic-Clonic Seizure (GTCS), Temporal Lobe Epilepsy (TLE), Absence Seizure, Myoclonus, and Status Epilepticus (SE) Models. Researchers leverage these models to gain critical insights into epilepsy’s underlying causes, available therapies, and potential therapeutic targets. The study digs into a thorough analysis of the benefits and drawbacks related to various chemical models used in epilepsy treatment. This dual approach adds to the continuing discussion in epilepsy research by clarifying the complicated issues surrounding therapeutic strategies and improving our understanding of the complexity of epilepsy. This article includes discusses GTCS, SE, and TLE subtypes such as WAG/Rij rats, coriaria lactone-induced TLE, pilocarpine-induced TLE, Tottering 6j mouse, GHB-induced seizure model, PTZ-induced model, NMDA-induced seizure models, and flurothyl-induced seizure model. Penicillin-induced TLE, Theiler’s virus-induced TLE, and many more.