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Suicidal Behavior in major affective disorders and their relationships with severity of depressive symptoms, inflammation, and childhood maltreatment
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  • Sandra Odebrecht Vargas Nunes,
  • Gisele de Souza Teixeira Bellinello,
  • Mariana Urbano,
  • Heber Odebrecht Vargas,
  • Waldiceu Verri,
  • Ana Car olina Roussanais
Sandra Odebrecht Vargas Nunes
Universidade Estadual de Londrina Centro de Ciencias da Saude

Corresponding Author:[email protected]

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Gisele de Souza Teixeira Bellinello
Universidade Estadual de Londrina Centro de Ciencias da Saude
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Mariana Urbano
Universidade Estadual de Londrina Centro de Ciencias da Saude
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Heber Odebrecht Vargas
Universidade Estadual de Londrina Centro de Ciencias da Saude
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Waldiceu Verri
Universidade Estadual de Londrina Centro de Ciencias da Saude
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Ana Car olina Roussanais
Universidade Estadual de Londrina Centro de Ciencias da Saude
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Abstract

Background: The aim of this study was to investigate whether individuals with and without a history of lifetime suicide attempts had differences in more severe depressive, anxious, and manic symptoms, functional impairment, quality of life, and childhood maltreatment, besides cytokines Method: The cross-sectional study enrolled 54 suicide attempters and 154 non-suicide attempters. All individuals were assessed through a questionnaire, structured clinical interview (SCID) for diagnoses of major affective disorders, and scales (17 item-Hamilton Depression Rating Scale, Young Mania Rating Scale, Hamilton Anxiety Rating Scale, Sheehan Disability Scale, Childhood Trauma Questionnaire and Quality of life). We also assessed anthropometric measures and laboratory biomarkers . Results: Individuals with history of lifetime suicide attempts showed significantly positive correlations regarding soluble tumor necrosis factor receptor 1 (sTNF–RI) and severity of depressive symptoms (p= 0.013); interleukin-1 receptor antagonist (IL-1RA) and severity of depressive symptoms (p= 0.04); absenteeism from work and childhood physical abuse (p= 0.012). Suicide attempters presented higher levels of interleukins (IL-13, IL-5), interferon-gamma (IFNγ), granulocyte-macrophage colony-stimulating factor (GM-CSF), and lower IL-4 levels. Conclusions: The data suggest that a subgroup of patients with history of lifetime suicide attempts in major affective disorders was associated with childhood maltreatment and pro- and anti-inflammatory cytokines.