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Comparison of dopamine release and uptake parameters across sex, species and striatal subregions
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  • Lindsey Kuiper,
  • Alyssa West,
  • Emily DiMarco,
  • Emma Galante,
  • Monica Dawes,
  • Kenneth Kishida,
  • Sara Jones
Lindsey Kuiper
Wake Forest University School of Medicine
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Alyssa West
Wake Forest University School of Medicine
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Emily DiMarco
Wake Forest University School of Medicine
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Emma Galante
Wake Forest University School of Medicine
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Monica Dawes
Wake Forest University School of Medicine
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Kenneth Kishida
Wake Forest University School of Medicine
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Sara Jones
Wake Forest University School of Medicine

Corresponding Author:[email protected]

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Abstract

For over three decades, fast scan cyclic voltammetry (FSCV) has been used to selectively measure neurotransmitters such as dopamine (DA) with high spatial and temporal resolution, providing detailed information about regulation of DA in the extracellular space. FSCV is an optimal method for determining concentrations of stimulus-evoked DA in brain tissue. When modeling diseases involving disturbances in DA transmission, preclinical rodent models are especially useful because of the availability of specialized tools and techniques that serve as a foundation for translational research. There is known heterogeneity in DA dynamics between and within DA-innervated brain structures and between males and females. However, systematic evaluations of sex- and species-differences across multiple areas are lacking. Therefore, using FSCV, we captured a broad range of DA dynamics across five sub-regions of the dorsal and ventral striatum of males and females of both rats and mice that reflect the functional heterogeneity of DA kinetics and dynamics within these structures. While numerous differences were found, in particular we documented a strong, consistent pattern of increased DA transporter activity in females in all of the regions surveyed. The data herein are intended to be used as a resource for further investigation of DA terminal function.
14 Oct 2023Submitted to European Journal of Neuroscience
17 Oct 2023Assigned to Editor
17 Oct 2023Submission Checks Completed
17 Oct 2023Review(s) Completed, Editorial Evaluation Pending
17 Oct 2023Reviewer(s) Assigned
11 Nov 2023Editorial Decision: Revise Major