Immunometabolic stress and herbal medicines in atherosclerosis
AbstractAtherosclerosis is a widespread illness that gravely endangers human
health and is the fundamental pathological foundation of many
cardiovascular and cerebrovascular diseases. The absorption and storage
of oxidatively modified LDL by certain specofoc cells in immune cells,
such as macrophages, causes varieties of immunooxidative processes.
These processes of stress lead to plaque rupture through inflammatory
processes, and then drives the development of atherosclerotic lesions.
Now, the medications for the treatment of atherosclerosis are mostly
lipid-lowering, anticoagulant, and thrombolytic agents, but the
therapeutic outcomes are insufficient. It is determined that traditional
Chinese medicine has achieved good clinical efficacy in treating
atherosclerotic illnesses. However, the mechanism of TCM therapy for
atherosclerosis needs to be elucidated. This paper highlights the target
mechanism and structural features of traditional Chinese medicine
components and compounds in controlling the connections mentioned above
and then regulating atherosclerosis, hoping to propose novel techniques
for treating and preventing the disease.