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Antibody mimetics: the next generation antibody engineering, a retrospective and prospective analysis
  • Siran Zhang,
  • Longjiang Wu,
  • Mei Dang
Siran Zhang
Xi’an Middle School of Shaanxi Province
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Longjiang Wu
Shaanxi University of Technology
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Mei Dang
Shaanxi University of Technology

Corresponding Author:[email protected]

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Antibody mimetics is a novel antibody engineering approach after the development of polyclonal, monoclonal antibodies, and genetically engineered antibody fragments. Inspired by the structure and function of natural antibodies, antibody mimetics offer many advantages over conventional antibodies and can be constructed by protein-directed evolution, peptide design and synthesis, or fusion of complementarity-determining regions through intervening framework regions. A series of parent protein/peptide structures and technical roadmaps have been established to induce better recognising properties, superior affinity, stability, penetrability, and cost-effectiveness of the designed mimetics. This article aims to summarise the evolution of antibody mimetics engineering, illustrate the highlights and hotpots in this research field using scientometric analysis, and give an anticipatory analysis on this increasing research topic.
07 Oct 2023Submitted to Biotechnology Journal
10 Oct 2023Submission Checks Completed
10 Oct 2023Assigned to Editor
22 Oct 2023Review(s) Completed, Editorial Evaluation Pending
22 Oct 2023Editorial Decision: Revise Major
21 Nov 20231st Revision Received
22 Nov 2023Submission Checks Completed
22 Nov 2023Assigned to Editor
22 Nov 2023Review(s) Completed, Editorial Evaluation Pending
22 Nov 2023Reviewer(s) Assigned