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Prognostic Relevance of CXCL13 and IL-8 Biomarkers in Predicting the Transition from Clinically Isolated Syndrome to Multiple Sclerosis
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  • Kateřina Klíčová,
  • Jan Mares,
  • Ondřej Sobek,
  • Zuzana Rous,
  • Matouš Rous,
  • Milan Raška,
  • Hans-Peter Hartung
Kateřina Klíčová
Palacky University Olomouc

Corresponding Author:[email protected]

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Jan Mares
Palacky University Olomouc
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Ondřej Sobek
Laboratory for Cerebrospinal Fluid, Neuroimmunology, Pathology and Special Diagnostics Topelex
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Zuzana Rous
Faculty of Medicine and Dentistry, Palacký University and University Hospital
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Matouš Rous
Faculty of Medicine and Dentistry, Palacký University and University Hospital
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Milan Raška
Palacky University Olomouc Faculty of Medicine and Dentistry
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Hans-Peter Hartung
Faculty of Medicine and Dentistry, Palacký University and University Hospital
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Abstract

Aims: The initial phase of multiple sclerosis (MS), often known as clinically isolated syndrome (CIS), is a critical period for identifying individuals at high risk of progressing to full-blown MS and initiating timely treatment. In this study, we aimed to evaluate the prognostic value of CXCL13 and IL-8 as potential markers for CIS patients’ conversion to MS. Methods: Our study encompassed patients with CIS, those with relapsing-remitting MS (RRMS), and control subjects, with sample analysis conducted on both cerebrospinal fluid (CSF) and serum. Patients were categorized into four groups: CIS-CIS (no MS development within two years), CIS-RRMS (conversion to RRMS within two years), RRMS (already diagnosed), and a control group (CG) with non-inflammatory CNS disorders. Results: Results showed significantly elevated levels of CXCL13 in CSF across all patient groups compared to the CG (p < 0.0001, Kruskal-Wallis test). Although CXCL13 concentrations were slightly higher in the CIS-RRMS group, statistical significance was not reached. Similarly, significantly higher levels of IL-8 were detected in CSF samples from all patient groups compared to the CG (p < 0.0001, Kruskal-Wallis test), with comparable levels among patient groups. ROC analysis in the CIS-RRMS group identified both CXCL13 (AUC = 0.959) and IL-8 (AUC = 0.939) in CSF as significant predictors of CIS to RRMS conversion. Conclusion: In conclusion, our study suggests a trend toward elevated CXCL13 levels in CIS patients progressing to RRMS. These findings emphasize the importance of identifying prognostic markers to guide appropriate treatment strategies for individuals in the early stages of MS.
05 Oct 2023Submitted to European Journal of Neuroscience
05 Oct 2023Assigned to Editor
05 Oct 2023Submission Checks Completed
05 Oct 2023Review(s) Completed, Editorial Evaluation Pending
05 Oct 2023Reviewer(s) Assigned
13 Nov 2023Editorial Decision: Revise Major