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Geraniol attenuates oxidative stress and neuro-inflammation mediated cognitive impairment in D galactose induced mouse-aging model
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  • Peramaiyan Rajendran,
  • Fatma J Al-Saeedi,
  • Rebai Ben Ammar,
  • Basem M Abdallah,
  • Enas Ali Abdelkader,
  • Vishnu Priya Veeraraghavan,
  • Sarah Abdulaziz Alamer,
  • Gamal M. Bekhet,
  • Emad A Ahmed,
  • Mohammed Salem Moqbel,
  • Saeed Y Al-Ramadan
Peramaiyan Rajendran
King Faisal University

Corresponding Author:[email protected]

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Fatma J Al-Saeedi
Kuwait University
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Rebai Ben Ammar
King Faisal University
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Basem M Abdallah
King Faisal University
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Enas Ali Abdelkader
King Faisal University
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Vishnu Priya Veeraraghavan
Saveetha Institute of Medical and Technical Sciences (Deemed to be University) Saveetha Dental College
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Sarah Abdulaziz Alamer
King Faisal University
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Gamal M. Bekhet
King Faisal University
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Emad A Ahmed
King Faisal University
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Mohammed Salem Moqbel
King Faisal University
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Saeed Y Al-Ramadan
King Faisal University
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Abstract

Background and Purpose D-galactose (D-gal) administration was proven. to induce cognitive impairment, Alzheimer disease and aging in rodents’ models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. Herein, we examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuro-inflammation mediated memory loss in mice. Experimental Approach The study was conducted using six group of mice (6 mice per group). The Ist group received normal saline, then D-gal (150 mg/wt) dissolved in normal saline solution (0.9%, w/v) was given orally for 9 weeks to the second group. From the second week until the 10th week, mice were treated orally (without anesthesia) with D-gal (150 mg/wt) followed by GNL (40 mg/kg/wt) four hours later. Mice of group IV were treated with GNL from the second week up until the end of the experiment. The therapeutic effects of GNL on D-gal-induced oxidative stress and neuro-inflammation mediated memory loss in mice was evaluated. For comparison of young versus elderly mice, (Group V) and 16 (what are 4 and 6) (group VI) month old control mice were used. Key Results Administration of GNL induced a significant increase in spatial learning and memory with spontaneously altered behavior. This effects was mediated through improving anti-oxidant and anti-inflammatory levels and activating PI3K/Akt. Further, GNL treatment upregulated the NRF-2 and HO-1 to reduce the oxidative stress and apoptosis. That was confirmed using 99mTc-HMPAO brain flow gamma bioassays. Conclusion and Implications Geraniol could be used as a promising agent in treating neuro-inflammation induced cognitive impairment.