Background and aims: This study aimed to identify studies that provide comprehensive information on the biological-molecular changes of inflammatory breast cancer (IBC) from January 1, 2000, to the end of November 2021. Methods: Two researchers independently searched electronic databases using keywords and Boolean operators. Inclusion criteria included studies published in English, peer-reviewed, and with appropriate information on IBC’s biological-molecular changes. Exclusion criteria were studies not in English, those without sufficient information on molecular and biological processes related to cancer, or those including other cancers. Results: From an initial selection of 1639 studies, 11 were selected based on the inclusion and exclusion criteria. The results highlight the importance of rigorous search strategies in identifying relevant studies in the field of cancer research. Conclusions: Understanding the unique traits of inflammatory breast cancer is crucial in determining its aggressive nature. Differential diagnosis of IBC from other types of breast cancer is necessary as genetic and molecular alterations in IBC are also present in non-IBC breast cancer, despite potential differences in treatment.