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Evaluation of Aqueous Methanol Stem Bark Extract of Stereospermum kunthianum for Wound Healing Effects in Alloxan-induced Diabetic Rats
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  • Chekwube Ifeadi,
  • Florence Nwinyi,
  • Julius Ode,
  • Jonas Onah,
  • Ramon-Yusuf Babatunde
Chekwube Ifeadi
University of Abuja Faculty of Veterinary Medicine

Corresponding Author:[email protected]

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Florence Nwinyi
University of Abuja
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Julius Ode
University of Abuja
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Jonas Onah
University of Abuja
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Ramon-Yusuf Babatunde
University of Abuja
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Abstract

• BACKGROUND AND PURPOSE: The stem bark of Stereospermum kunthianum is used extensively in traditional medicine to treat wounds, inflammatory and other pain related health conditions in humans. The aim of this study was to evaluate the wound healing properties of the stem bark extract of S. kunthianum in alloxan-induced diabetic rats. • EXPERIMENTAL APPROACH: The aqueous methanol extract of S. kunthianum was analyzed for phytochemical constituents, acute toxicity tests in rats. The stem bark extract of S. kunthianum was evaluated for wound healing using excision and incision wound healing models in diabetic rats. • KEY RESULTS: The aqueous methanol extract of S. kunthianum revealed that saponins, terpenes, tannins and steroids were present. The acute toxicity study in rats up to 72 hrs. showed no observed toxicity sign up to the dose of 5000 mg/kg .The S. kunthianum stem bark extract (100, 200, 400 mg/kg, p.o) caused significant reduction of wound area. The excision wound contraction (%) in rats treated with S. kunthianum stem bark extract was most effective and had 100% wound contraction. In the incision wound studies, the S. kunthianum stem bark extract showed a progressive rate of wound repair with increasing doses of the extract. • CONCLUSION: The results corroborated the ethno-medicinal claims and have given the scientific justification for the use of S. kunthianum stem bark extract for wound healing. • IMPLICATION: The S. kunthianum stem bark extract therefore has the potential to be developed as a wound healing agent.