The HPV viral regulatory mechanism of TLRs and the Related treatments
for HPV-Associated Cancers
Infection with human papillomavirus (HPV) typically leads to cervical
cancer, skin related cancers and many other tumors. HPV is mainly
responsible for evading immune tumor monitoring in HPV related cancers.
Toll like receptors (TLRs) are particular pattern recognition molecules.
When the body is facing immune danger, it can lead to innate and direct
adaptive immunity. TLR plays an important role in initiating antiviral
immune responses. HPV can affect the expression level of TLR and
interfere with TLR related signaling pathways, resulting in sustained
viral infection and even carcinogenesis. This paper introduces the HPV
virus and HPV related cancers. We discussed the present comprehension of
TLR, its expression and signaling, as well as its role in HPV infection.
We also provided a detailed introduction to immunotherapy methods for
HPV related diseases based on TLR agonists. This will provide insights
into methods that support the therapeutic method of HPV related
conditions with TLR agonists.