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Gaps in Diagnosing Suspected Infection in Immunocompromised Children with Cancer: A Systematic Review
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  • Sarah Y. Park,
  • Nicole G. Coufal,
  • Samuel Dominguez,
  • Lauge Farnaes,
  • Kevin Messacar,
  • Frederick Goldman
Sarah Y. Park
Karius Inc

Corresponding Author:[email protected]

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Nicole G. Coufal
University of California San Diego Department of Pediatrics
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Samuel Dominguez
University of Colorado Anschutz Medical Campus Department of Pediatrics
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Lauge Farnaes
Karius Inc
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Kevin Messacar
University of Colorado Anschutz Medical Campus Department of Pediatrics
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Frederick Goldman
The University of Alabama at Birmingham Division of Hematology and Oncology
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While the survival of children with cancer has improved over time, infection remains a major morbidity and mortality risk. We conducted a systematic literature review to determine the unmet needs in diagnosing infection in immunocompromised children with cancer. The comprehensive search strategy followed the guidelines established by the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement and spanned multiple bibliographic databases and other public sources from January 1, 2012–June 23, 2022. From 5,188 records, 34 unique pediatric-focused studies met inclusion criteria. This review highlights the lack of published data on infectious disease testing in pediatric oncology patients and the need for well-designed clinical impact and cost-effectiveness studies of both existing and novel diagnostic platforms. Such studies are necessary to optimize diagnostic and antimicrobial stewardship, leading to improvement in patient outcomes.
22 Sep 2023Submitted to Pediatric Blood & Cancer
22 Sep 2023Submission Checks Completed
22 Sep 2023Assigned to Editor
25 Sep 2023Review(s) Completed, Editorial Evaluation Pending
25 Sep 2023Reviewer(s) Assigned
03 Nov 2023Editorial Decision: Revise Minor
17 Nov 2023Submission Checks Completed
17 Nov 2023Assigned to Editor
17 Nov 20231st Revision Received
17 Nov 2023Review(s) Completed, Editorial Evaluation Pending
18 Nov 2023Editorial Decision: Accept