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Water soluble cellulose regulates intestinal flora and improves insulin resistance
  • hong Long,
  • shibing Zhang,
  • tingyang Qin
hong Long
Zunyi Medical College

Corresponding Author:[email protected]

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shibing Zhang
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tingyang Qin
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Abstract

In recent years, a number of clinical studies and animal experiments have confirmed that dietary fiber affects blood glucose metabolism by regulating intestinal flora. However, the correlation between dietary fiber and insulin resistance and the intermediate metabolites of insulin resistance are not completely clear. Water soluble cellulose (SDF) can selectively promote the growth and activity of some beneficial bacteria, so as to enhance the proliferation and function of beneficial bacteria. In the analysis of intestinal microbial population change, compared with Chow group, the relative abundance of Prevotella and bacteroides in feces of HFD group was significantly higher and Roseburia was significantly lower; Compared with HFD group, the relative abundance of Prevotella in F-HFD group decreased significantly, indicating that Prevotella may be an intestinal target microorganism for SDF to improve insulin resistance (IR) in rats fed high-fat diet. Based on the related metabolites of Prevotella, we detected the contents of branched chain amino acids (BCAAs) in serum of rats in each group. The results showed that the content of BCAAs in serum of chow group was significantly lower than that of HFD group. Correlation analysis showed that BCAAs was significantly positively correlated with IR and glucose tolerance, positively correlated with Prevotella, and negatively correlated with oscillospira and Roseburia. Therefore, SDF may reduce the production of BCAAs by regulating the abundance of Prevotella in the intestinal flora of rats fed with high-fat diet, so as to reduce IR.