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Cellular Pathways and Biomarkers in Breast Cancer: Insights into HPV+ Association and Prognostic Significance Shortened title: Pathways and Biomarkers in HPV-Breast Cancer
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  • Antonio Carlos de Freitas,
  • Vanessa Emanuelle Pereira Santos,
  • Pedro Luiz de França Neto,
  • Bruna Isabel Santos Cruz,
  • Stephanie Loureiro Leão,
  • Beatriz Mendonça Alves Bandeira,
  • Anna Jéssica Duarte Silva,
  • Benigno Cristofer Flores Espinoza,
  • Larissa Silva de Macêdo,
  • Matheus do Nascimento Carvalho,
  • Nathálya Lima de Queiroz,
  • Ingrid Andrêssa de Moura,
  • Mylenna Máyra Gois de Sousa,
  • Daffany Luana dos Santos,
  • Bianca de França São Marcos,
  • Beatriz Eda de Oliveira Isídio,
  • Thainá de Almeida Lima,
  • Maria da Conceição Viana Invenção
Antonio Carlos de Freitas
Universidade Federal de Pernambuco Centro de Biociencias

Corresponding Author:[email protected]

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Vanessa Emanuelle Pereira Santos
Universidade Federal de Pernambuco Centro de Biociencias
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Pedro Luiz de França Neto
Universidade Federal de Pernambuco Centro de Biociencias
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Bruna Isabel Santos Cruz
Universidade Federal de Pernambuco Centro de Biociencias
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Stephanie Loureiro Leão
Universidade Federal de Pernambuco Centro de Biociencias
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Beatriz Mendonça Alves Bandeira
Universidade Federal de Pernambuco Centro de Biociencias
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Anna Jéssica Duarte Silva
Universidade Federal de Pernambuco Centro de Biociencias
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Benigno Cristofer Flores Espinoza
Universidade Federal de Pernambuco Centro de Biociencias
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Larissa Silva de Macêdo
Universidade Federal de Pernambuco Centro de Biociencias
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Matheus do Nascimento Carvalho
Universidade Federal de Pernambuco Centro de Biociencias
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Nathálya Lima de Queiroz
Universidade Federal de Pernambuco Centro de Biociencias
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Ingrid Andrêssa de Moura
Universidade Federal de Pernambuco Centro de Biociencias
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Mylenna Máyra Gois de Sousa
Universidade Federal de Pernambuco Centro de Biociencias
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Daffany Luana dos Santos
Universidade Federal de Pernambuco Centro de Biociencias
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Bianca de França São Marcos
Universidade Federal de Pernambuco Centro de Biociencias
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Beatriz Eda de Oliveira Isídio
Universidade Federal de Pernambuco Centro de Biociencias
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Thainá de Almeida Lima
Universidade Federal de Pernambuco Centro de Biociencias
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Maria da Conceição Viana Invenção
Universidade Federal de Pernambuco Centro de Biociencias
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Abstract

Breast cancer is one of the leading global neoplasms and represents a primary form of cancer affecting women. The role of HPV in breast cancer development is acknowledged, yet the underlying mechanism remains incompletely understood. Biomarkers are crucial tools for diagnosis, prognosis, and disease monitoring, encompassing HPV-associated cancers. While hormonal receptors, Ki-167, and HER2 are well-established in breast cancer, additional markers assume significance, particularly in aiding disease monitoring, thereby facilitating the categorization and targeting of patients within specific risk cohorts. Infectious and carcinogenic processes disrupt the activity of diverse signaling pathways. Signaling through pro-inflammatory pathways, notably linked to IL-6 overexpression, is prominently documented in these cases, along with the activation of NF-κB, β-catenin/Wnt, and Pi3/AKT signaling pathways. This review delineates the main altered pathways in HPV-positive breast cancer. The study of this molecular landscape can help the identification of suitable biomarkers for assisting the follow-up of HPV-positive breast cancer. Furthermore, it unveils potential targets warranting exploration for targeted therapies directed at breast cancer.