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Magnetic Fe-Ni bimetallic oxide shell nanorods containing anti-protein polymer segments for protein purification
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  • Ting Wang,
  • Yanting Lyu,
  • Mudasir Ahmad,
  • Baoliang Zhang
Ting Wang
Northwestern Polytechnical University
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Yanting Lyu
Northwestern Polytechnical University School of Chemistry and Chemical Engineering
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Mudasir Ahmad
Northwestern Polytechnical University
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Baoliang Zhang
Northwestern Polytechnical University

Corresponding Author:[email protected]

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In this paper, BSA surface-imprinted magnetic Fe-Ni bimetallic oxide shell nanorods (m-FeNi@MIPs@PCBMA) were prepared with the assistance of poly(3-[[2-(methacryloyloxy)ethyl]dimethylammonium] propionate (PCBMA) in connection with the surface-imprinting technique. The Fe-Ni bimetallic oxide shell layer nanorods (m-FeNi) with magnetic responsiveness simplified the separation and recovery process of adsorbed materials. The controlled introduction of PCBMA facilitated the reduction of protein non-specific adsorption. At the optimal encapsulation ratio of 1:0.75 (Wm-FeNi@MIPs: WCBMA), m-FeNi@MIPs@PCBMA could adsorb 122.98 ± 5 mg/g of BSA within 80 min, and the value of the imprinting factor (IF) was also increased from 1.68 (m-FeNi@MIPs) to 3.95. In the mixed protein adsorption and real sample separation experiments, m-FeNi@MIPs@PCBMA could selectively separate BSA. Meanwhile, after seven adsorption-desorption experiments, the loss of BSA adsorption by the imprinted nanorods was only 15.9%, which had good reusability. Therefore, m-FeNi@MIPs@PCBMA has a broader application prospect in the field of protein separation and purification.
12 Sep 2023Submitted to AIChE Journal
13 Sep 2023Assigned to Editor
13 Sep 2023Submission Checks Completed
13 Sep 2023Review(s) Completed, Editorial Evaluation Pending
14 Sep 2023Reviewer(s) Assigned
21 Nov 2023Editorial Decision: Revise Minor