Association of ITGA2 Dual Site Variants with Recurrent Ischemic Events
in Patients Undergoing Stenting for Symptomatic Intracranial
Objective: We aimed to investigate the relationship between
gene polymorphisms and the occurrence of adverse clinical events
following dual antiplatelet therapy in Patients with Symptomatic
Intracranial Atherosclerotic Stenosis. Methods: A total of 195
patients were enrolled, categorized into 32 cases (those with clinical
adverse events) and 163 controls (without events). Genotyping of 20 SNPs
from 17 genes was executed. Statistical analyses (Fisher’s exact test,
logistic regression) were applied to determine associations.
Results: The ITGA2 rs1126643 (C807T) and rs1062535 (G873A)
polymorphisms were significantly correlated with adverse clinical
events. Specifically, the mutant frequency of allele C (ITGA2 rs1126643)
and allele G (ITGA2 rs1062535) was significantly higher in cases
compared to controls (OR = 2.97, 95%CI = 1.702-5.172, P = 0.0001; OR =
3.27, 95%CI = 1.762-6.066, P = 0.0002, respectively). Other genotypes
showed no significant differences between the groups.
Conclusion: The ITGA2 C807T and G873A polymorphisms may elevate
the risk of vascular events in Chinese patients. Detecting these
polymorphisms may be valuable in identifying patients at risk of
recurrent ischemic events.