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Redox regulation in chloroplast thylakoid lumen: The pmf changes everything, again.
  • Donghee Hoh,
  • John E. Froehlich,
  • David M. Kramer
Donghee Hoh
MSU-DOE Plant Research Laboratory

Corresponding Author:[email protected]

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John E. Froehlich
MSU-DOE Plant Research Laboratory
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David M. Kramer
MSU-DOE Plant Research Laboratory
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Photosynthesis is the foundation of all life on Earth, providing oxygen and energy. However, if not well regulated, it can also generate toxic reactive oxygen species (ROS), which can cause photodamage. Regulation of photosynthesis is highly dynamic, responding to both environmental and metabolic cues, and occurs at many levels, from light capture to energy storage and metabolic processes. One general mechanism of regulation involves the reversible oxidation and reduction of protein thiol groups, which can affect the activity of enzymes and the stability of proteins. Such redox regulation has been well studied in stromal enzymes, but more recently evidence has emerged of redox control of thylakoid lumenal enzymes. This review/hypothesis paper summarizes the latest research and discusses several open questions and challenges to achieving effective redox control in the lumen, focusing on the distinct environments and regulatory components of the thylakoid lumen, including the need to transport electrons across the thylakoid membrane, the effects of pH changes in the stromal and lumenal compartments, and the observed differences in redox states. These constraints suggest that activated oxygen species are likely to be major regulatory contributors to lumenal thiol redox regulation, with key components and processes yet to be discovered.
04 Sep 2023Submitted to Plant, Cell & Environment
04 Sep 2023Submission Checks Completed
04 Sep 2023Assigned to Editor
09 Sep 2023Review(s) Completed, Editorial Evaluation Pending
11 Sep 2023Reviewer(s) Assigned
06 Oct 2023Editorial Decision: Revise Minor
06 Nov 20231st Revision Received
06 Nov 2023Submission Checks Completed
06 Nov 2023Assigned to Editor
11 Nov 2023Review(s) Completed, Editorial Evaluation Pending
13 Nov 2023Reviewer(s) Assigned