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Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix.
  • +3
  • jinhao Jia,
  • jianfei Chen,
  • guoli Wang,
  • Minjing Li,
  • Defang Li,
  • Qiusheng Zheng
jinhao Jia
Binzhou Medical University
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jianfei Chen
Binzhou Medical University
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guoli Wang
Binzhou Medical University
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Minjing Li
Binzhou Medical University
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Defang Li
Binzhou Medical University

Corresponding Author:[email protected]

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Qiusheng Zheng
Binzhou Medical University
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Abstract

The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a traditional Chinese herbal medicine (CHM), it possesses multiple effects, including analgesia, sedation, anti-inflammation, antioxidation, anti-tumor, immunomodulation, cardiovascular and cerebrovascular regulation, and nerve damage repair, and it has been widely used in clinical practice. In recent years, scientists have extensively studied the active components and pharmacological effects of RR. Active ingredients mainly include iridoid glycosides (such as catalpol and aucuboside), phenylpropanoid glycosides (such as acteoside), other saccharides, and unsaturated fatty acids. In addition, the Chinese patent medicine (CPM) and Chinese decoction related to RR have also become major research subjects for TCM practitioners; one example is the Bolus of Six Drugs, which includes Rehmannia, Lily Bulb and Rehmannia Decoction, and Siwu Decoction. This article reviews recent literature on RR; summarizes the studies on its chemical constituents, pharmacological effects, and clinical applications; and analyzes the progress and limitations of current investigations to provide reference for further exploration and development of RR.