loading page

((Commentary on pmic.202300239 - title of the commentary t.b.a.)) Beyond the model organism – Mechanistic analysis of protein post-translational modifications is ready for all challengers
  • Benjamin Orsburn
Benjamin Orsburn
The Johns Hopkins University School of Medicine

Corresponding Author:[email protected]

Author Profile


A historic challenge for shotgun proteomics has been the requirement for high quality, simple and nonredundant curated protein sequences in small .fasta text files. Due to the intrinsic informatic challenges and time required to assemble these files, proteomics has struggled to expand beyond the confines of a few model organisms. When considering post-translational modifications that may or may not be present on a specific peptide sequence, these factors inevitably compound. A study on how mangos continue to ripen on the shelf may not be the first thing you'd think of as proof of a scientific discipline shedding historic limitations. However, Bautiste-Valle et al., may be just that. These authors present a quantitative comparison of both peptide and glycopeptide alterations through the complexity of the fruit ripening process and in this we see the present state of a field that no longer needs to wait on genomics to obtain deep mechanistic insights.
29 Aug 2023Submitted to PROTEOMICS
31 Aug 2023Assigned to Editor
31 Aug 2023Submission Checks Completed
31 Aug 2023Review(s) Completed, Editorial Evaluation Pending
31 Aug 2023Editorial Decision: Accept