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Total Saponins from Panax Japonicus Promote Lipolysis of Aging Fat Through the Tyrosine Hydroxylase Signaling Pathway
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  • Chengfu Yuan,
  • Mengzhen Xue,
  • Wei Wu,
  • Jiale Zhao,
  • Leiqi Zhu,
  • Yaqi Wang,
  • Fangqi Xia,
  • Yuanyang Li,
  • Yifan Zhang,
  • Yaqi Hu,
  • Shuwen Wang,
  • Rui Wang,
  • Qi Yuan,
  • Yibei Gui,
  • Xueqing Li,
  • Lijun Wang,
  • Hailin Wang,
  • Yiyang Luo,
  • Ding Yuan,
  • * Yumin,
  • Xueliang Ding
Chengfu Yuan
China Three Gorges University

Corresponding Author:[email protected]

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Mengzhen Xue
China Three Gorges University
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Wei Wu
China Three Gorges University
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Jiale Zhao
China Three Gorges University
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Leiqi Zhu
China Three Gorges University
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Yaqi Wang
China Three Gorges University
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Fangqi Xia
China Three Gorges University
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Yuanyang Li
China Three Gorges University
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Yifan Zhang
China Three Gorges University
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Yaqi Hu
China Three Gorges University
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Shuwen Wang
China Three Gorges University
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Rui Wang
China Three Gorges University
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Qi Yuan
China Three Gorges University
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Yibei Gui
China Three Gorges University
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Xueqing Li
China Three Gorges University
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Lijun Wang
China Three Gorges University
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Hailin Wang
China Three Gorges University
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Yiyang Luo
China Three Gorges University
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Ding Yuan
Three Gorges University College of Medical Science
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* Yumin
China Three Gorges University
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Xueliang Ding
Three Gorges University College of Medical Science
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Abstract

Aging and obesity are closely related, and the prevalence of obesity and metabolic diseases are rapidly increasing with an aging population worldwide. A key change in the adipose tissue during the aging process is the decline of lipolysis, and the excitation of the sympathetic nerve system is a key pathway to promote lipolysis. Previous studies have shown that the total saponins from Panax japonicus (TSPJs) can prevent obesity in mice with high-fat diet by increasing fat decomposition. In this work, we examine the regulatory effects of TSPJs on lipolysis in the aging state and explore the possible mechanisms. TSPJs can promote the excitation of sympathetic nerves by increasing the expression of tyrosine hydroxylase in the adipose tissue, which positively regulates the expression of lipases to revitalize lipolysis. The results suggest that TSPJs can help to resist aging-induced obesity and may be a potential medication for weight management.