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Update on Pharmacological Activities, Security, and Pharmacokinetics of Aloe-emodin
  • +4
  • Haimeng Luo,
  • Xiaoyun Ji,
  • Mengyu Zhang,
  • Yaoyao Ren,
  • Rui Tan,
  • Hezhong Jiang,
  • Xiaoqing Wu
Haimeng Luo
Southwest Jiaotong University School of Life Science and Engineering
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Xiaoyun Ji
Southwest Jiaotong University School of Life Science and Engineering
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Mengyu Zhang
Southwest Jiaotong University School of Life Science and Engineering
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Yaoyao Ren
Southwest Jiaotong University
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Rui Tan
Southwest Jiaotong University
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Hezhong Jiang
Southwest Jiaotong University
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Xiaoqing Wu
Southwest Jiaotong University School of Life Science and Engineering

Corresponding Author:[email protected]

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Abstract

Aloe-emodin (AE), a naturally occurring anthraquinone derivative, represents one of the principal active components found in various Chinese herbs such as Cassia occidentalis, Rheum palmatum L., Aloe vera, and Polygonum multiflorum Thunb. AE has been shown to possess a diverse range of pharmacological effects including anticancer, antivirus, anti-inflammatory, antibacterial, neuroprotective, and hepatoprotective properties. These remarkable therapeutic attributes provide a solid foundation for treating an array of diseases ranging from influenza virus, inflammation, sepsis, Alzheimer’s disease, glaucoma, malaria, liver fibrosis, psoriasis, Type 2 diabetes, growth disorders, and several types of cancers. However, despite its promising potential, clinical application of AE is somewhat limited by poor intestinal absorption, short elimination half-life, and low bioavailability. Furthermore, AE may exhibit potential liver and kidney toxicity. Therefore, this paper aims to review the pharmacological effects of AE along with its mechanism, pharmacokinetics, and safety studies, in order to offer valuable insights into the development and application of AE.