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Ex-vivo study of Herb -- Drug Interaction
  • Ujban Hussain,
  • Samiksha Tammewar,
  • Ayush Mishra
Ujban Hussain
Priyadarshini J. L College of pharmacy

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Samiksha Tammewar
Priyadarshini J. L. College of Pharmacy
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Ayush Mishra
R C Patel Institute of Pharmaceutical Education and Research
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Abstract

The aim of the present study is to evaluate the effect of some food ingredients on intestinal absorption of metronidazole in the presence of asafoetida, ginger, and lemon juice using the Ex-vivo technique of non-everted ileum preparation. It was found that the intervals of the drug were decreasing with time over 2hrs in the absence of ginger, lemon juice, and as a combination of these food ingredients. The effect of these foods on the therapeutic efficacy of the synthetic drug was studied in a glucocorticoid inhibition model using rabbits.