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Cobalt-Catalyzed Difunctionalization of Styrenes Enabled by Ligand Relay Catalysis
  • Bingcheng Wang,
  • Yufeng Sun,
  • Zhan Lu
Bingcheng Wang
Zhejiang University
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Yufeng Sun
Zhejiang University
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Zhan Lu
Zhejiang University

Corresponding Author:[email protected]

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Here, we report a cobalt-catalyzed sequential dehydrogenative Heck silylation/hydroamination of styrenes with hydrosilane and diazo compound to access 1-amino-2-silyl compounds with excellent regioselectivity. This difunctionalization reaction could undergo smoothly using 1 mol% catalyst loading with good functional group tolerance. Not only di- and tri-substituted hydrosilanes, but also alkoxysilane are suitable, which does explore the scope of the family of 1-amino-2-silyl compounds. The ligand relay phenomenon between neutral tridentate NNN ligand and anionic NNN ligand is observed for the first time via absorption spectra analysis in this one-pot, two-step transformations. The primary mechanism has been proposed based on the control experiments.
24 Aug 20231st Revision Received
25 Aug 2023Assigned to Editor
25 Aug 2023Submission Checks Completed
25 Aug 2023Review(s) Completed, Editorial Evaluation Pending
27 Aug 2023Editorial Decision: Accept