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A systematic review of global guidelines for the diagnosis of penicillin allergy
  • Yuanchao Guo,
  • Ting He,
  • Yunzhu Lin
Yuanchao Guo
Sichuan University West China Second University Hospital Department of Pharmacy
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Ting He
Sichuan University West China School of Pharmacy
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Yunzhu Lin
Sichuan University West China Second University Hospital Department of Pharmacy

Corresponding Author:[email protected]

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Objective: This study aimed to evaluate the global guidelines on diagnostic methods for penicillin allergy and to provide evidence for regulating diagnostic procedures for penicillin allergy. Methods: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang database, VIP database, Clinical Guidelines database, World Bank GDP ranking of the top 15 countries of the health sector, multinational organisations and related societies websites were searched. The AGREE II instrument was used to evaluate the methodology and reporting quality of the guidelines. Results: 34 articles were included, from 14 countries and regions, including ten government and intergovernmental organisation guidance documents, nine clinical guidelines, and 15 expert consensuses. After AGREE Ⅱ evaluation, the overall quality of the included literature was not high, and most of the literature did not show a systematic, rigorous production process. There are apparent differences in the recommendations of each literature, including the diagnosis object, time, method and approach. Conclusion: The methods of allergy diagnosis for penicillin allergy differ significantly from country to country around the world, mainly in terms of diagnostic target, diagnostic staff, timing, diagnostic steps, diagnostic reagents and determination of results, with the main gaps being in the diagnostic steps and diagnostic reagents, and further original studies are expected to compare the advantages and disadvantages of each protocol.